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Colorectal cancer screening by family-history risk

HIGH-YIELD Appears 4×
Teaching point

Risk-stratify colorectal screening by family history. Average/near-average risk (no family history, or a single FDR diagnosed at >=55-60) gets iFOBT every 2 years (ages 45-74). HNPCC/Lynch (autosomal dominant) needs colonoscopy every 1-2 years from age 25 (or 5 years younger than the earliest affected relative), with attention to endometrial/ovarian risk in women.

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