Umbilical (Sister Mary Joseph) nodule - intra-abdominal malignancy

HIGH-YIELD Appears 2×

Teaching point

Weight loss, obstructive jaundice and constitutional symptoms with an umbilical nodule (Sister Mary Joseph nodule) indicate advanced intra-abdominal malignancy (cholangiocarcinoma/gallbladder carcinoma), distinct from acute cholangitis (Charcot triad without weight loss) or cholecystitis.

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